Journal of Movement Disorders

Seong-Beom Koh

21 Articles

A Practical Guide for Clinical Approach to Patients With Huntington’s Disease in Korea: Chaewon Shin, Ryul Kim, Dallah Yoo, Eungseok Oh, Jangsup Moon, Minkyeong Kim, Jee-Young Lee, Jong-Min Kim, Seong-Beom Koh, Manho Kim, Beomseok Jeon; J Mov Disord. 2024;17(2):138-149. Published online March 12, 2024; DOI: https://doi.org/10.14802/jmd.24040

659 View
53 Download
2 Comments

PDF

Caregiver Burden of Patients With Huntington’s Disease in South Korea: Chan Young Lee, Chaewon Shin, Yun Su Hwang, Eungseok Oh, Manho Kim, Hyun Sook Kim, Sun Ju Chung, Young Hee Sung, Won Tae Yoon, Jin Whan Cho, Jae-Hyeok Lee, Han-Joon Kim, Hee Jin Chang, Beomseok Jeon, Kyung Ah Woo, Seong-Beom Koh, Kyum-Yil Kwon, Jangsup Moon, Young Eun Kim, Jee-Young Lee; J Mov Disord. 2024;17(1):30-37. Published online September 11, 2023; DOI: https://doi.org/10.14802/jmd.23134

2,024 View
161 Download
1 Comments

Abstract PDF Supplementary Material: Objective
This is the first prospective cohort study of Huntington’s disease (HD) in Korea. This study aimed to investigate the caregiver burden in relation to the characteristics of patients and caregivers.
Methods
From August 2020 to February 2022, we enrolled patients with HD from 13 university hospitals in Korea. We used the 12-item Zarit Burden Interview (ZBI-12) to evaluate the caregiver burden. We evaluated the clinical associations of the ZBI-12 scores by linear regression analysis and investigated the differences between the low- and high-burden groups.
Results
Sixty-five patients with HD and 45 caregivers were enrolled in this cohort study. The average age at onset of motor symptoms was 49.3 ± 12.3 years, with an average cytosine-adenine-guanine (CAG)n of 42.9 ± 4.0 (38–65). The median ZBI-12 score among our caregivers was 17.6 ± 14.2. A higher caregiver burden was associated with a more severe Shoulson–Fahn stage (p = 0.038) of the patients. A higher ZBI-12 score was also associated with lower independence scale (B = -0.154, p = 0.006) and functional capacity (B = -1.082, p = 0.002) scores of patients. The caregiving duration was longer in the high- than in the low-burden group. Caregivers’ demographics, blood relation, and marital and social status did not affect the burden significantly.
Conclusion
HD patients’ neurological status exerts an enormous impact on the caregiver burden regardless of the demographic or social status of the caregiver. This study emphasizes the need to establish an optimal support system for families dealing with HD in Korea. A future longitudinal analysis could help us understand how disease progression aggravates the caregiver burden throughout the entire disease course.

Hair Loss: A Well-Known Yet Understudied Symptom in Parkinson’s Disease Patients During Dopaminergic Therapy: Jungyeun Lee, Hwa Jung Ryu, Soon Young Hwang, Seong-Beom Koh; J Mov Disord. 2024;17(1):47-54. Published online September 26, 2023; DOI: https://doi.org/10.14802/jmd.23088

1,123 View
98 Download

Abstract PDF Supplementary Material: Objective
Hair loss has been reported to occur during dopaminergic therapy in patients with Parkinson’s disease. The mechanism by which dopaminergic therapy induces hair loss is not well understood. Dopamine receptors are present in the hair follicle, where they regulate melanin production. However, the role of dopamine receptors in hair growth is still not well understood. This study aimed to evaluate the prevalence of hair loss and identify factors associated with complaints of hair loss in patients with Parkinson’s disease.
Methods
A cross-sectional design involving 495 Parkinson’s disease patients was applied to evaluate hair loss status. Patients completed a questionnaire, and scalp/hair examinations were performed. Patients with underlying conditions that could affect hair loss and those prescribed medications known to increase the risk of hair loss were excluded. Finally, 291 patients (58.8%) were included for analysis.
Results
Among the 495 patients, 138 (27.9%) reported hair loss. Interestingly, more than half of the patients who complained of hair loss (79 out of 138) did not utilize treatments such as hair products, massage, dietary modifications, or alopecia medications. Hair inspection by a single investigator revealed objective hair loss in 263 patients (53.1%). An analysis of factors associated with hair loss complaints showed that the intake of dopaminergic medications with a levodopa-equivalent daily dose > 448 mg was associated with complaints of hair loss.
Conclusion
Dopaminergic medication is associated with hair loss complaints in Parkinson’s disease patients.

Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia: Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Ryu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim; J Mov Disord. 2023;16(1):86-90. Published online December 20, 2022; DOI: https://doi.org/10.14802/jmd.22137

1,550 View
91 Download

Abstract PDF Supplementary Material: Objective
The International Cooperative Ataxia Rating Scale (ICARS) is a semiquantitative clinical scale for ataxia that is widely used in numerous countries. The purpose of this study was to investigate the validity and reliability of the Korean-translated version of the ICARS.
Methods
Eighty-eight patients who presented with cerebellar ataxia were enrolled. We investigated the construct validity using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). We also investigated the internal consistency using Cronbach’s α and intrarater and interrater reliability using intraclass correlation coefficients.
Results
The Korean-translated ICARS showed satisfactory construct validity using EFA and CFA. It also revealed good interrater and intrarater reliability and showed acceptable internal consistency. However, subscale 4 for assessing oculomotor disorder showed moderate internal consistency.
Conclusion
This is the first report to investigate the validity and reliability of the Korean-translated ICARS. Our results showed excellent construct and convergent validity. The reliability is also acceptable.

Dance Intervention Using the Feldenkrais Method Improves Motor, and Non-Motor Symptoms and Gait in Parkinson’s Disease: A 12-Month Study: Sung Hoon Kang, Jinhee Kim, Ilsoo Kim, Young Ae Moon, Sojung Park, Seong-Beom Koh; J Mov Disord. 2022;15(1):53-57. Published online November 3, 2021; DOI: https://doi.org/10.14802/jmd.21086

4,324 View
380 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material

Objective
The aim of this study was to assess the effects of dancing (using the Feldenkrais method) on motor and non-motor symptoms, quality of life (QoL), and objective parameters of gait at the time of intervention and at the end of the 1-year study period.
Methods
This was a single-arm study in which 12 subjects with Parkinson’s disease (PD) received dance intervention during a 6-month period. Objective motor scales, gait analysis, and questionnaires on non-motor symptoms were evaluated at baseline and at 3, 6, and 12 months.
Results
Dance intervention decreased motor scale (Unified Parkinson’s Disease Rating Scale and Tinetti scale) scores and improved gait disturbance (gait velocity and step length) without increasing levodopa equivalent dose. Furthermore, dancing decreased non-motor scale (Non-Motor Symptoms Scale and Montgomery-Asberg Depression Rating Scale) scores and improved QoL.
Conclusion
Our findings suggest that dance intervention can be a complementary management method for PD patients.

Citations

Citations to this article as recorded by

Mild cognitive impairment is associated with poor gait performance in patients with Parkinson’s disease
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef

Constipation is Associated With Mild Cognitive Impairment in Patients With de novo Parkinson’s Disease: Sung Hoon Kang, Jungyeun Lee, Seong-Beom Koh; J Mov Disord. 2022;15(1):38-42. Published online November 17, 2021; DOI: https://doi.org/10.14802/jmd.21074

4,276 View
314 Download
2 Web of Science
3 Crossref

Abstract PDF

Objective
The association between gastrointestinal (GI) symptoms and cognitive profile in patients with Parkinson’s disease (PD) at diagnosis remains unclear, although GI symptoms and cognitive impairment are highly prevalent in patients with PD. We investigated the relationship between constipation and cognitive status. We also aimed to identify the correlation between constipation and each neuropsychological dysfunction.
Methods
A total of 427 patients with de novo Parkinson’s disease with normal cognition (PD-NC, n = 170) and Parkinson’s disease with mild cognitive impairment (PD-MCI, n = 257) at Korea University Guro Hospital in Seoul, Korea were included. All patients underwent comprehensive neuropsychological tests and completed the Non-Motor Symptoms Scale (NMSS). The frequency and severity of constipation were assessed using the NMSS GI symptoms scale, we used logistic regression analysis and partial correlation analysis to determine the associations between constipation score, MCI, and each neuropsychological dysfunction.
Results
Frequent and severe constipation was associated with MCI in patients with PD at diagnosis regardless of disease severity. Specifically, constipation was related to poor performance in frontal-executive and visuospatial functions after controlling for age and sex.
Conclusion
Our findings may provide an understanding of constipation as a marker associated with cognitive impairment in individuals with PD. Therefore, the evaluation of cognitive function is warranted in PD patients with constipation, while further studies are necessary to investigate the detailed mechanism of our results.

Citations

Citations to this article as recorded by

Defecation after magnesium supplementation enhances cognitive performance in triathletes
Chen-Chan Wei, M. Brennan Harris, Mengxin Ye, Andrew Nicholls, Ahmad Alkhatib, Luthfia Dewi, Chi-Yang Huang, Chia-Hua Kuo
Sports Medicine and Health Science.2024;[Epub] CrossRef
Constipation in Parkinson's Disease
Eamonn M. M. Quigley
Seminars in Neurology.2023; 43(04): 562. CrossRef
Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism
Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef

The Four Square Step Test for Assessing Cognitively Demanding Dynamic Balance in Parkinson’s Disease Patients: Jinhee Kim, Ilsoo Kim, Ye Eun Kim, Seong-Beom Koh; J Mov Disord. 2021;14(3):208-213. Published online May 26, 2021; DOI: https://doi.org/10.14802/jmd.20146

4,773 View
161 Download
5 Web of Science
5 Crossref

Abstract PDF Supplementary Material

Objective
The Four Square Step Test (FSST) is a tool that assesses dynamic balance during obstacle step-over. To date, few studies have used the FSST to measure balance in patients with Parkinson’s disease (PD). This study aimed to verify that patients with PD, even at the de novo early stage, take more time to perform the FSST and identify which factors, cognitive status or cardinal motor symptoms, are related most to FSST scores.
Methods
Thirty-five newly diagnosed drug-naïve patients with PD and 17 controls completed the FSST. The Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, spatiotemporal gait parameters, and neuropsychological test battery were also assessed in the PD group.
Results
Mean FSST performance time was 8.20 ± 1.61 seconds in patients with PD, which was significantly more than the control group (7.13 ± 1.10 seconds, p = 0.018). UPDRS part III total score and H&Y stage were not significantly associated with FSST, but among the UPDRS subscores, only the postural instability/gait disturbance subscore showed a significant association. Regarding the association between FSST and cognition, the Trail Making Test-B and the Color Word Stroop Test showed strongly inverse correlations with FSST (rho = -0.598 and -0.590, respectively). With respect to gait parameters, double support time was significantly associated with FSST score (rho = 0.342, p = 0.044); however, other parameters, including velocity and step length, were not associated with the FSST.
Conclusion
The FSST can be used in the clinic to assess dynamic balance with cognitive demands even in the early stages of PD.

Citations

Citations to this article as recorded by

Impact of mobile phone usage on dynamic postural control among South Indian college students
S. Dhanusia, S. Santhana Lakshmi, Ajith Kumar, R. Prabhu, Vignesh Srinivasan, Prathap Suganthirababu, Priyadharshini Kumar, A. Kumaresan, Surya Vishnuram, Jagatheesan Alagesan, Rajkumar Krishnan Vasanthi
Work.2024; : 1. CrossRef
A Computer Vision-Based System to Help Health Professionals to Apply Tests for Fall Risk Assessment
Jesús Damián Blasco-García, Gabriel García-López, Marta Jiménez-Muñoz, Juan Antonio López-Riquelme, Jorge Juan Feliu-Batlle, Nieves Pavón-Pulido, María-Trinidad Herrero
Sensors.2024; 24(6): 2015. CrossRef
2023 Carol B. Lewis Distinguished Lecture Address to the APTA Geriatrics Membership Combined Sections Meeting, February 23, 2023 Key Words & Challenges: Defining Our Role in Caring for Older Adults
Michelle M. Lusardi
Journal of Geriatric Physical Therapy.2023; 46(2): 93. CrossRef
The relationship between visual function and physical performance in the Study of Muscle, Mobility and Aging (SOMMA)
Atalie C. Thompson, Eileen Johnson, Michael E. Miller, Jeff D. Williamson, Anne B. Newman, Steve Cummings, Peggy Cawthon, Stephen B. Kritchevsky, Eric R. Anson
PLOS ONE.2023; 18(9): e0292079. CrossRef
Relationship between parental history of dementia, motor-cognitive and executive function performance in African American women
Allison A. Bay, Nicole Schindler, Whitney Wharton, Hayley Silverstein, Liang Ni, Todd A. Prusin, Madeleine E. Hackney
Journal of the Neurological Sciences.2022; 439: 120305. CrossRef

Clinical Characteristics of Involuntary Movement in Hospitalized Patients: Kyum-Yil Kwon, Hye Mi Lee, Seon-Min Lee, Seong-Beom Koh; J Mov Disord. 2019;12(1):31-36. Published online December 20, 2018; DOI: https://doi.org/10.14802/jmd.18040

6,910 View
204 Download
2 Web of Science
2 Crossref

Abstract PDF

Objective
Neurological symptoms in hospitalized patients are not rare, and neurological consultation for movement disorders is especially important in evaluating or managing those with various movement disorders. Therefore, we investigated a clinical pattern of in-hospital consultations for various movement disorders in a tertiary care university hospital.
Methods
Over two years, a total of 202 patients (70.7 ± 11.8 years of age) presenting with movement disorders referred to movement disorder specialists were investigated.
Results
The main symptoms referred by nonneurologists were tremor (56.9%), parkinsonism (16.8%), and gait disturbance (8.9%). The most frequent diagnostic category was toxic/metabolic-caused movement disorder (T/MCMD) (35%) with regard to medications, followed by Parkinson’s disease (PD) (16%). Regarding the mode of onset, T/MCMD was the leading cause for acute (68%) and subacute onset (46%), while PD was the leading disorder (31%) for chronic onset.
Conclusion
The current study showed a characteristic pattern of inpatients presenting with movement disorders. Furthermore, our findings highlighted the clinical significance of drug use or metabolic problems for treating this patient population.

Citations

Citations to this article as recorded by

Pattern and frequency of involuntary movements: hospital-based study
H. N. El Tallawy, A. S. Shalash, M. A. Abdelhamed, R. E. Elsabrout
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2023;[Epub] CrossRef
Clinical Spectrum of Movement Disorders in Neurology Inpatients in a Tertiary Care Centre
Shabeer Ahmad Paul, Gouranga Prasad Mondal, Ramesh Bhattacharyya, Kartik Chandra Ghosh, Sarbajit Das, Suman Das, Hema Krishna, Chandrakanta Patra
Journal of Neurosciences in Rural Practice.2021; 12: 581. CrossRef

Validity and Reliability Study of the Korean Tinetti Mobility Test for Parkinson’s Disease: Jinse Park, Seong-Beom Koh, Hee Jin Kim, Eungseok Oh, Joong-Seok Kim, Ji Young Yun, Do-Young Kwon, Younsoo Kim, Ji Seon Kim, Kyum-Yil Kwon, Jeong-Ho Park, Jinyoung Youn, Wooyoung Jang; J Mov Disord. 2018;11(1):24-29. Published online January 23, 2018; DOI: https://doi.org/10.14802/jmd.17058

11,140 View
263 Download
14 Web of Science
13 Crossref

Abstract PDF Supplementary Material

Objective
Postural instability and gait disturbance are the cardinal symptoms associated with falling among patients with Parkinson’s disease (PD). The Tinetti mobility test (TMT) is a well-established measurement tool used to predict falls among elderly people. However, the TMT has not been established or widely used among PD patients in Korea. The purpose of this study was to evaluate the reliability and validity of the Korean version of the TMT for PD patients.
Methods
Twenty-four patients diagnosed with PD were enrolled in this study. For the interrater reliability test, thirteen clinicians scored the TMT after watching a video clip. We also used the test-retest method to determine intrarater reliability. For concurrent validation, the unified Parkinson’s disease rating scale, Hoehn and Yahr staging, Berg Balance Scale, Timed-Up and Go test, 10-m walk test, and gait analysis by three-dimensional motion capture were also used. We analyzed receiver operating characteristic curve to predict falling.
Results
The interrater reliability and intrarater reliability of the Korean Tinetti balance scale were 0.97 and 0.98, respectively. The interrater reliability and intra-rater reliability of the Korean Tinetti gait scale were 0.94 and 0.96, respectively. The Korean TMT scores were significantly correlated with the other clinical scales and three-dimensional motion capture. The cutoff values for predicting falling were 14 points (balance subscale) and 10 points (gait subscale).
Conclusion
We found that the Korean version of the TMT showed excellent validity and reliability for gait and balance and had high sensitivity and specificity for predicting falls among patients with PD.

Citations

Citations to this article as recorded by

Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia
Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Ryu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim
Journal of Movement Disorders.2023; 16(1): 86. CrossRef
Reliability and validity of the Tinetti performance oriented mobility assessment in Chinese community-dwelling older adults
Chen Yang, Yihan Mo, Xi Cao, Song Zhu, Xiuhua Wang, Xiaoqing Wang
Geriatric Nursing.2023; 53: 85. CrossRef
Validation of the Performance Oriented Mobility Assessment (Tinetti Test) Scale in Russia for Stroke Patients
Elena V. Kostenko, Liudmila V. Petrova, Irena V. Pogonchenkova
Bulletin of Rehabilitation Medicine.2023; 22(3): 29. CrossRef
Dance Intervention Using the Feldenkrais Method Improves Motor, and Non-Motor Symptoms and Gait in Parkinson’s Disease: A 12-Month Study
Sung Hoon Kang, Jinhee Kim, Ilsoo Kim, Young Ae Moon, Sojung Park, Seong-Beom Koh
Journal of Movement Disorders.2022; 15(1): 53. CrossRef
Evaluation of Anticipatory Postural Adjustment before Quantified Weight Shifting—System Development and Reliability Test
Jiunn-Woei Liaw, Rou-Shayn Chen, Vincent Chiun-Fan Chen, Yan-Ru Wang, Hsiao-Lung Chan, Ya-Ju Chang
Applied Sciences.2021; 11(2): 758. CrossRef
Use of Standardized and Non-Standardized Tools for Measuring the Risk of Falls and Independence in Clinical Practice
Jan Neugebauer, Valérie Tóthová, Jitka Doležalová
International Journal of Environmental Research and Public Health.2021; 18(6): 3226. CrossRef
Decreased foot height may be a subclinical shuffling gait in early stage of Parkinson’s disease: A study of three-dimensional motion analysis
Kyong Jin Shin, Jinse Park, Samyeol Ha, Kang Min Park, Sung Eun Kim, Byung In Lee, Dong Ah Lee, Hee-Tae Kim, Ji-Yeon Yoon
Gait & Posture.2020; 76: 64. CrossRef
Design of a Machine Learning-Assisted Wearable Accelerometer-Based Automated System for Studying the Effect of Dopaminergic Medicine on Gait Characteristics of Parkinson’s Patients
Satyabrata Aich, Pyari Mohan Pradhan, Sabyasachi Chakraborty, Hee-Cheol Kim, Hee-Tae Kim, Hae-Gu Lee, Il Hwan Kim, Moon-il Joo, Sim Jong Seong, Jinse Park
Journal of Healthcare Engineering.2020; 2020: 1. CrossRef
Psychometric properties and domains of postural control tests for individuals with knee osteoarthritis: a systematic review
Helen P. French, Charlotte K. Hager, Anne Venience, Ryan Fagan, Dara Meldrum
International Journal of Rehabilitation Research.2020; 43(2): 102. CrossRef
Measures of balance and falls risk prediction in people with Parkinson’s disease: a systematic review of psychometric properties
Stanley J Winser, Priya Kannan, Umar Muhhamad Bello, Susan L Whitney
Clinical Rehabilitation.2019; 33(12): 1949. CrossRef
Allelic variant in SLC6A3 rs393795 affects cerebral regional homogeneity and gait dysfunction in patients with Parkinson’s disease
Lina Wang, Yongsheng Yuan, Jianwei Wang, Yuting Shen, Yan Zhi, Junyi Li, Min Wang, Kezhong Zhang
PeerJ.2019; 7: e7957. CrossRef
Evaluation of Balance Disorders in Parkinson's Disease Using Simple Diagnostic Tests—Not So Simple to Choose
Karolina Krzysztoń, Jakub Stolarski, Jan Kochanowski
Frontiers in Neurology.2018;[Epub] CrossRef
Rasch Analysis of the Clinimetric Properties of the Korean Dizziness Handicap Inventory in Patients with Parkinson Disease
Da-Young Lee, Hui-Jun Yang, Dong-Seok Yang, Jin-Hyuk Choi, Byoung-Soo Park, Ji-Yun Park
Research in Vestibular Science.2018; 17(4): 152. CrossRef

Quantitative Gait Analysis in Patients with Huntington’s Disease: Seon Jong Pyo, Hanjun Kim, Il Soo Kim, Young-Min Park, Mi-Jung Kim, Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2017;10(3):140-144. Published online August 31, 2017; DOI: https://doi.org/10.14802/jmd.17041

7,275 View
141 Download
17 Web of Science
18 Crossref

Abstract PDF

Objective
Gait disturbance is the main factor contributing to a negative impact on quality of life in patients with Huntington’s disease (HD). Understanding gait features in patients with HD is essential for planning a successful gait strategy. The aim of this study was to investigate temporospatial gait parameters in patients with HD compared with healthy controls.
Methods
We investigated 7 patients with HD. Diagnosis was confirmed by genetic analysis, and patients were evaluated with the Unified Huntington’s Disease Rating Scale (UHDRS). Gait features were assessed with a gait analyzer. We compared the results of patients with HD to those of 7 age- and sex-matched normal controls.
Results
Step length and stride length were decreased and base of support was increased in the HD group compared to the control group. In addition, coefficients of variability for step and stride length were increased in the HD group. The HD group showed slower walking velocity, an increased stance/swing phase in the gait cycle and a decreased proportion of single support time compared to the control group. Cadence did not differ significantly between groups. Among the UHDRS subscores, total motor score and total behavior score were positively correlated with step length, and total behavior score was positively correlated with walking velocity in patients with HD.
Conclusion
Increased variability in step and stride length, slower walking velocity, increased stance phase, and decreased swing phase and single support time with preserved cadence suggest that HD gait patterns are slow, ataxic and ineffective. This study suggests that quantitative gait analysis is needed to assess gait problems in HD.

Citations

Citations to this article as recorded by

Sensor-Based Locomotion Data Mining for Supporting the Diagnosis of Neurodegenerative Disorders: A Survey
Samaneh Zolfaghari, Sumaiya Suravee, Daniele Riboni, Kristina Yordanova
ACM Computing Surveys.2024; 56(1): 1. CrossRef
The semicircular canal function is preserved with little impact on falls in patients with mild Parkinson's disease
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Parkinsonism & Related Disorders.2024; 118: 105933. CrossRef
Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease
Veronika Ratz-Wirsching, Johanna Habermeyer, Sandra Moceri, Julia Harrer, Christoph Schmitz, Stephan von Hörsten
Frontiers in Neuroscience.2024;[Epub] CrossRef
Wearable sensors and features for diagnosis of neurodegenerative diseases: A systematic review
Huan Zhao, Junyi Cao, Junxiao Xie, Wei-Hsin Liao, Yaguo Lei, Hongmei Cao, Qiumin Qu, Chris Bowen
DIGITAL HEALTH.2023; 9: 205520762311735. CrossRef
Spatiotemporal Gait Parameters in Adults With Premanifest and Manifest Huntington’s Disease: A Systematic Review
Sasha Browning, Stephanie Holland, Ian Wellwood, Belinda Bilney
Journal of Movement Disorders.2023; 16(3): 307. CrossRef
Walking pattern analysis using GAIT cycles and silhouettes for clinical applications
S.M.H. Sithi Shameem Fathima, K.A. Jyotsna, Thiruveedula Srinivasulu, Kande Archana, M. Tulasi rama, S. Ravichand
Measurement: Sensors.2023; 30: 100893. CrossRef
Human Gait Analysis in Neurodegenerative Diseases: A Review
Grazia Cicirelli, Donato Impedovo, Vincenzo Dentamaro, Roberto Marani, Giuseppe Pirlo, Tiziana R. D'Orazio
IEEE Journal of Biomedical and Health Informatics.2022; 26(1): 229. CrossRef
Development of Neuro-Degenerative Diseases’ Gait Classification Algorithm Using Convolutional Neural Network and Wavelet Coherence Spectrogram of Gait Synchronization
Febryan Setiawan, An-Bang Liu, Che-Wei Lin
IEEE Access.2022; 10: 38137. CrossRef
Artificial intelligence in neurodegenerative diseases: A review of available tools with a focus on machine learning techniques
Alexandra-Maria Tăuţan, Bogdan Ionescu, Emiliano Santarnecchi
Artificial Intelligence in Medicine.2021; 117: 102081. CrossRef
Identification of Neurodegenerative Diseases Based on Vertical Ground Reaction Force Classification Using Time–Frequency Spectrogram and Deep Learning Neural Network Features
Febryan Setiawan, Che-Wei Lin
Brain Sciences.2021; 11(7): 902. CrossRef
The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
Nicollette L. Purcell, Jennifer G. Goldman, Bichun Ouyang, Yuanqing Liu, Bryan Bernard, Joan A. O’Keefe, Pedro Gonzalez-Alegre
PLOS ONE.2020; 15(1): e0226827. CrossRef
Gait variability as digital biomarker of disease severity in Huntington’s disease
Heiko Gaßner, Dennis Jensen, F. Marxreiter, Anja Kletsch, Stefan Bohlen, Robin Schubert, Lisa M. Muratori, Bjoern Eskofier, Jochen Klucken, Jürgen Winkler, Ralf Reilmann, Zacharias Kohl
Journal of Neurology.2020; 267(6): 1594. CrossRef
Evaluation of Vertical Ground Reaction Forces Pattern Visualization in Neurodegenerative Diseases Identification Using Deep Learning and Recurrence Plot Image Feature Extraction
Che-Wei Lin, Tzu-Chien Wen, Febryan Setiawan
Sensors.2020; 20(14): 3857. CrossRef
Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington’s disease
P. Stepanova, V. Srinivasan, D. Lindholm, M. H. Voutilainen
Scientific Reports.2020;[Epub] CrossRef
Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease
Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C. Park, Ignacio Munoz-Sanjuan, Yuqing Li
PLOS ONE.2020; 15(12): e0243052. CrossRef
Rule based classification of neurodegenerative diseases using data driven gait features
Kartikay Gupta, Aayushi Khajuria, Niladri Chatterjee, Pradeep Joshi, Deepak Joshi
Health and Technology.2019; 9(4): 547. CrossRef
Discovery of Arginine Ethyl Ester as Polyglutamine Aggregation Inhibitor: Conformational Transitioning of Huntingtin N-Terminus Augments Aggregation Suppression
Virender Singh, Kinjal A. Patel, Raj Kumar Sharma, Pratik R. Patil, Abhayraj S. Joshi, Rashmi Parihar, Thamarailingam Athilingam, Neeraj Sinha, Subramaniam Ganesh, Pradip Sinha, Ipsita Roy, Ashwani Kumar Thakur
ACS Chemical Neuroscience.2019; 10(9): 3969. CrossRef
Gait Biomarkers Classification by Combining Assembled Algorithms and Deep Learning: Results of a Local Study
Eddy Sánchez-DelaCruz, Roberto Weber, R. R. Biswal, Jose Mejía, Gandhi Hernández-Chan, Heberto Gómez-Pozos
Computational and Mathematical Methods in Medicine.2019; 2019: 1. CrossRef

Patients and Their Caregivers’ Burdens for Parkinson’s Disease in Korea: Jong Sam Baik, Joong-Seok Kim, Seong-Beom Koh, Jin Whan Cho, Phil Hyu Lee, Hyeo-Il Ma, Yun Joong Kim, Tae-Beom Ahn, Sang Jin Kim, Yong Duk Kim, Seong-min Choi, Ho-Won Lee, Hee Tae Kim; J Mov Disord. 2017;10(3):109-115. Published online September 22, 2017; DOI: https://doi.org/10.14802/jmd.17053

7,177 View
225 Download
11 Web of Science
11 Crossref

Abstract PDF

Objective
Many patients with Parkinson’s disease (PD) suffer from motor and non-motor symptoms. According to these variable symptoms of PD, patients or caregivers have a poorer quality of life than patients with other neurodegenerative diseases. Since the difficulties are varied for all patients, prioritizing their difficulties differs among all cases. The goal of this study was to investigate the burdens of PD among the caregivers as well as patients and to identify areas requiring aid from the government.
Methods
We surveyed the awareness and perceptions of PD in patients and caregivers of PD by a face-to-face questionnaire. The questionnaire was divided into three sections: symptoms of PD (part A), desire for policies (part B), and difficulties faced by their caregivers (part C). Part A comprised 8 questions, Part B had 2 questions, and Part C had 3 questions.
Results
In total, 853 subjects (702 patients and 151 caregivers) were enrolled in this study. The major difficulties experienced by PD patients were physical (67%), psychiatric (60%) and socio-economic (52%). Assessing the physical difficulties, more than half the patients experienced severe difficulties (29% very severe, 39% severe). Psychiatric difficulties were assessed as severe (35%) and very severe (21%) among the patients. Severe difficulties were also experienced socio-economically, at 52% in patients and 49% in caregivers, especially among patients in their fifties (58%) and those with their spouse (65%) as caregivers. The topmost need was the introduction of new technology for treatment of PD (62%), followed by relief of costs for treatment (38%) and a family support system (31%). The majority (91%) of the patients were diagnosed with PD within two years after onset of symptoms.
Conclusion
We know that the difficulties of PD and the needs for government assistance are different between patients and caregivers. These results emphasize that perceiving the difficulties and needs of patients and caregivers early can help to prevent and ameliorate the burden of disease.

Citations

Citations to this article as recorded by

Challenges in Parkinson’s Disease Care—In Light of the COVID-19 Pandemic
Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
Journal of Movement Disorders.2023; 16(1): 52. CrossRef
Efficacy and safety of a combination of emotional freedom technique with acupuncture versus acupuncture alone to treat psychiatric symptoms in Parkinson’s disease: A protocol for a randomized, assessor-blind, parallel-group clinical trial
Dong-Hoon Kang, Ju-Yeon Kim, Yang-Chun Park, Ho-Ryong Yoo, In Chul Jung
Medicine.2023; 102(21): e33714. CrossRef
Exploring Unmet Information Needs of People with Parkinson’s Disease and Their Families: Focusing on Information Sharing in an Online Patient Community
Hyeon Sik Chu, Hye Young Jang
International Journal of Environmental Research and Public Health.2022; 19(5): 2521. CrossRef
Participants' perspective on a COVID-19 online vocal group stimulation for people with Parkinson's disease
Marie-Christine Hallé, Charline Delorme, Édith Coulombe, Ouswa Rekik, Ingrid Verduyckt
Frontiers in Rehabilitation Sciences.2022;[Epub] CrossRef
Group singing improves quality of life for people with Parkinson’s: an international study
J. Yoon Irons, Grenville Hancox, Trish Vella-Burrows, Eun-Young Han, Hyun-Ju Chong, David Sheffield, Donald E. Stewart
Aging & Mental Health.2021; 25(4): 650. CrossRef
Exploring the perceptions and stigmatizing experiences of Israeli family caregivers of people with Parkinson's disease
Hanan AboJabel, Einat Argavan, Sharon Hassin-Baer, Rivka Inzelberg, Perla Werner
Journal of Aging Studies.2021; 56: 100910. CrossRef
Perceived online social support for Parkinson’s disease patients: The role of support type, uncertainty, contentment, and psychological quality of life
Surin Chung, Eunjin (Anna) Kim, J. Brian Houston
Communication Quarterly.2021; 69(3): 259. CrossRef
Delivering patient-centered care in Parkinson's disease: Challenges and consensus from an international panel
Roongroj Bhidayasiri, Pattamon Panyakaew, Claudia Trenkwalder, Beomseok Jeon, Nobutaka Hattori, Priya Jagota, Yih-Ru Wu, Elena Moro, Shen-Yang Lim, Huifang Shang, Raymond Rosales, Jee-Young Lee, Win Min Thit, Eng-King Tan, Thien Thien Lim, Ngoc Tai Tran,
Parkinsonism & Related Disorders.2020; 72: 82. CrossRef
Understanding patients’ and caregivers’ perspectives and educational needs in Parkinson’s disease: a multi-ethnic Asian study
Xing Yan Choo, Shen-Yang Lim, Karuthan Chinna, Yan Jing Tan, Voon Wei Yong, Jia Lun Lim, Kar Foo Lau, Jing Yi Chung, Jun Min Em, Hui Ting Tan, Jia Hwa Lim, Seng Beng Tan, Chong Tin Tan, Ai Huey Tan
Neurological Sciences.2020; 41(10): 2831. CrossRef
Nörolojik Hastalık ve Evlilik
Mehmet ÖNGER, Tuba AYDIN
Sakarya Medical Journal.2020;[Epub] CrossRef
The burden of care and the understanding of disease in Parkinson’s disease
Geum-Bong Lee, Hyunhee Woo, Su-Yoon Lee, Sang-Myung Cheon, Jae Woo Kim, Oscar Arias-Carrion
PLOS ONE.2019; 14(5): e0217581. CrossRef

Sleepiness and Depression in Parkinson’s Disease Patients Treated with Ropinirole and Levodopa: Suk Yun Kang, Ho-Sung Ryu, Mun-Kyung Sunwoo, Sang-Jin Kim, Jong-Sam Baik, Mee-Young Park, Hyung-Eun Park, Joong-Seok Kim, Kyum-Yil Kwon, Seong-Beom Koh, Young-Eun Kim, Mi-Kyong Lee, Jong-Min Kim, Sun Ju Chung, Young-Ho Sohn; J Mov Disord. 2017;10(3):123-129. Published online September 22, 2017; DOI: https://doi.org/10.14802/jmd.17048

9,119 View
191 Download
12 Web of Science
10 Crossref

Abstract PDF

Objective
We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson’s disease (PD) with a large population.
Methods
We conducted a cross-sectional observational study at nine hospitals in Korea between April 24, 2013, and April 22, 2015. We analyzed the demographic and clinical features, other medical history, history of antiparkinsonian medication within 6 months, Hoehn and Yahr stage (HY stage), Unified Parkinson’s Disease Rating Scale (UPDRS) part II and III, Epworth Sleepiness Scale (ESS), and 30-item Geriatric Depression Scale (GDS-30).
Results
Four-hundred-thirteen patients with PD (mean age: 65.2 ± 9.0 years; men: 227 patients) were analyzed. Multivariate logistic regression analysis showed that age at examination, UPDRS II, and GDS-30 were independent risk factors for EDS and that sex, UPDRS II, and ESS were independent risk factors for depression.
Conclusion
Our large group study did not find any significant associations of ropinirole with EDS and depression in Korean PD patients.

Citations

Citations to this article as recorded by

Associations between non-motor symptoms and patient characteristics in Parkinson’s disease: a multicenter cross-sectional study
Remi Morimoto, Mutsumi Iijima, Yasuyuki Okuma, Keisuke Suzuki, Fumihito Yoshii, Shigeru Nogawa, Takashi Osada, Kazuo Kitagawa
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef
Excessive Daytime Sleepiness in Parkinson’s Disease
Hanshu Liu, Jingwen Li, Xinyi Wang, Jinsha Huang, Tao Wang, Zhicheng Lin, Nian Xiong
Nature and Science of Sleep.2022; Volume 14: 1589. CrossRef
Excessive daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis
Fei Feng, YingYing Cai, YanBing Hou, Ruwei Ou, Zheng Jiang, HuiFang Shang
Parkinsonism & Related Disorders.2021; 85: 133. CrossRef
Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study
Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo
Neuropsychology Review.2021; 31(4): 643. CrossRef
Longitudinal risk factors for developing depressive symptoms in Parkinson's disease
Tarek Antar, Huw R. Morris, Faraz Faghri, Hampton L. Leonard, Mike A. Nalls, Andrew B. Singleton, Hirotaka Iwaki
Journal of the Neurological Sciences.2021; 429: 117615. CrossRef
The effect and safety of ropinirole in the treatment of Parkinson disease
Jiali Zhu, Min Chen
Medicine.2021; 100(46): e27653. CrossRef
Pramipexole regulates depression-like behavior via dopamine D3 receptor in a mouse model of Parkinson’s disease
Shi-Zhuang Wei, Xiao-Yu Yao, Chen-Tao Wang, An-Qi Dong, Dan Li, Yu-Ting Zhang, Chao Ren, Jin-Bao Zhang, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Brain Research Bulletin.2021; 177: 363. CrossRef
A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats
Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A.C. Mondal
Neurochemistry International.2020; 136: 104730. CrossRef
‘Dopamine agonist Phobia’ in Parkinson’s disease: when does it matter? Implications for non-motor symptoms and personalized medicine
Silvia Rota, Iro Boura, Lucia Batzu, Nataliya Titova, Peter Jenner, Cristian Falup-Pecurariu, K Ray Chaudhuri
Expert Review of Neurotherapeutics.2020; 20(9): 953. CrossRef
An Investigation on the Clinical Features and Neurochemical Changes in Parkinson's Disease With Depression
Teng-Hong Lian, Peng Guo, Li-Jun Zuo, Yang Hu, Shu-Yang Yu, Li Liu, Zhao Jin, Qiu-Jin Yu, Rui-Dan Wang, Li-Xia Li, Ying-Shan Piao, Wei Zhang
Frontiers in Psychiatry.2019;[Epub] CrossRef

Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic: Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Young Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Eung Seok Oh, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Joong-Seok Kim; J Mov Disord. 2017;10(1):29-34. Published online January 18, 2017; DOI: https://doi.org/10.14802/jmd.16057

15,233 View
360 Download
29 Web of Science
30 Crossref

Abstract PDF Supplementary Material

Objective
Autonomic symptoms are commonly observed in patients with Parkinson’s disease (PD) and often limit the activities of daily living. The Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) was developed to evaluate and quantify autonomic symptoms in PD. The goal of this study was to translate the original SCOPA-AUT, which was written in English, into Korean and to evaluate its reliability and validity for Korean PD patients.
Methods
For the translation, the following processes were performed: forward translation, backward translation, expert review, pretest of the pre-final version and development of the final Korean version of SCOPA-AUT (K-SCOPA-AUT). In total, 127 patients with PD from 31 movement disorder clinics of university-affiliated hospitals in Korea were enrolled in this study. All patients were assessed using the K-SCOPA-AUT and other motor, non-motor, and quality of life scores. Test-retest reliability for the K-SCOPA-AUT was assessed over a time interval of 10−14 days.
Results
The internal consistency and reliability of the K-SCOPA-AUT was 0.727 as measured by the mean Cronbach’s α-coefficient. The test-retest correlation reliability was 0.859 by the Guttman split-half coefficient. The total K-SCOPA-AUT score showed a positive correlation with other non-motor symptoms [the Korean version of non-motor symptom scale (K-NMSS)], activities of daily living (Unified Parkinson’s Disease Rating Scale part II) and quality of life [the Korean version of Parkinson’s Disease Quality of Life 39 (K-PDQ39)].
Conclusion
The K-SCOPA-AUT had good reliability and validity for the assessment of autonomic dysfunction in Korean PD patients. Autonomic symptom severities were associated with many other motor and non-motor impairments and influenced quality of life.

Citations

Citations to this article as recorded by

Baseline prevalence and longitudinal assessment of autonomic dysfunction in early Parkinson’s disease
Lanqing Yang, Huan Gao, Min Ye
Journal of Neural Transmission.2024; 131(2): 127. CrossRef
Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
Journal of Movement Disorders.2023; 16(1): 59. CrossRef
Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson’s disease
Claudia Carricarte Naranjo, Claudia Sánchez Luaces, Ivonne Pedroso Ibáñez, Andrés Machado, Hichem Sahli, María Antonieta Bobes, Vincenzo De Luca
PLOS ONE.2023; 18(2): e0281959. CrossRef
Autonomic function and motor subtypes in Parkinson’s disease: a multicentre cross-sectional study
Si-Chun Gu, Rong Shi, Chen Gao, Xiao-Lei Yuan, You Wu, Zhen-Guo Liu, Chang-De Wang, Shao-Rong Zhao, Xiqun Chen, Can-Xing Yuan, Qing Ye
Scientific Reports.2023;[Epub] CrossRef
Clinical manifestation of patients with isolated rapid eye movement sleep behavior disorder after modest-to-long disease duration
Jung Kyung Hong, Jong-Min Kim, Ki-woong Kim, Ji Won Han, Soyeon Ahn, In-Young Yoon
Sleep.2022;[Epub] CrossRef
Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Rae On Kim, Eun Ji Lee, Mina Lee
Scientific Reports.2022;[Epub] CrossRef
Autonomic dysfunction in Parkinson's disease: Results from the Faroese Parkinson's disease cohort
Aksel Berg, Sára Bech, Jan Aasly, Matthew J. Farrer, Maria Skaalum Petersen
Neuroscience Letters.2022; 785: 136789. CrossRef
Prevalence of lower urinary tract symptoms, urinary incontinence and retention in Parkinson's disease: A systematic review and meta-analysis
Fang-Fei Li, Yu-Sha Cui, Rui Yan, Shuang-Shuang Cao, Tao Feng
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
Jung-Ick Byun, Seunghwan Oh, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Joon-Kyung Seong, Ki-Young Jung
NeuroImage: Clinical.2022; 36: 103186. CrossRef
Comparison of disease progression between brain-predominant Parkinson's disease versus Parkinson's disease with body-involvement phenotypes
Dong-Woo Ryu, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee, Seunggyun Ha, Joong-Seok Kim
Neurobiology of Disease.2022; 174: 105883. CrossRef
Corneal confocal microscopy differentiates patients with Parkinson’s disease with and without autonomic involvement
Ning-Ning Che, Shuai Chen, Qiu-Huan Jiang, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Rayaz A. Malik, Jian-Jun Ma, Hong-Qi Yang
npj Parkinson's Disease.2022;[Epub] CrossRef
Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder
Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Carlos H. Schenck, Sang Kun Lee, Ki-Young Jung
Journal of Clinical Neurology.2022; 18(5): 562. CrossRef
White Matter Tract-Specific Microstructural Disruption is Associated with Depressive Symptoms in Isolated Rbd
Jung-Ick Byun, Seunghwan Oh, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Joon-Kyung Seong, Ki-Young Jung
SSRN Electronic Journal .2022;[Epub] CrossRef
Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study
Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Man-Ho Kim, Han-Joon Kim, Won Chul Shin, Sang Kun Lee, Ki-Young Jung
Sleep Medicine.2021; 79: 88. CrossRef
Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Scientific Reports.2021;[Epub] CrossRef
Impact of motor subtype on non‐motor symptoms and fall‐related features in patients with early Parkinson's disease
Kyum‐Yil Kwon, Eun Ji Lee, Mina Lee, Hyunjin Ju, Kayeong Im
Geriatrics & Gerontology International.2021; 21(5): 416. CrossRef
Extra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson’s disease
Minkyeong Kim, Seulki Yoo, Doyeon Kim, Jin Whan Cho, Ji Sun Kim, Jong Hyun Ahn, Jun Kyu Mun, Inyoung Choi, Seung-Kyun Lee, Jinyoung Youn
Neurological Sciences.2021; 42(12): 5297. CrossRef
Clinical Assessment Scales in Autonomic Nervous System Disorders
Eun Bin Cho, Ki-Jong Park
Journal of the Korean Neurological Association.2021; 39(2 Suppl): 60. CrossRef
Cardiac sympathetic burden reflects Parkinson disease burden, regardless of high or low orthostatic blood pressure changes
Sang-Won Yoo, Joong-Seok Kim, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Ji-Yeon Yoo, Kwang-Soo Lee
npj Parkinson's Disease.2021;[Epub] CrossRef
Understanding fatigue in progressive supranuclear palsy
Jong Hyeon Ahn, Joomee Song, Dong Yeong Lee, Jinyoung Youn, Jin Whan Cho
Scientific Reports.2021;[Epub] CrossRef
Validation of the Korean version of the composite autonomic symptom scale 31 in patients with Parkinson’s disease
Jong Hyeon Ahn, Jin Myoung Seok, Jongkyu Park, Heejeong Jeong, Younsoo Kim, Joomee Song, Inyoung Choi, Jin Whan Cho, Ju-Hong Min, Byoung Joon Kim, Jinyoung Youn, Antonina Luca
PLOS ONE.2021; 16(10): e0258897. CrossRef
Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
Journal of Clinical Medicine.2021; 10(22): 5414. CrossRef
Characteristics of Autonomic Dysfunction in Parkinson’s Disease: A Large Chinese Multicenter Cohort Study
Zhou Zhou, Xiaoting Zhou, Xiaoxia Zhou, Yaqin Xiang, Liping Zhu, Lixia Qin, Yige Wang, Hongxu Pan, Yuwen Zhao, Qiying Sun, Qian Xu, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Zhenhua Liu
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef
Autonomic Dysfunction in Parkinson's Disease: Results from the Faroese Parkinson's Disease Cohort
Aksel Kambsskarð Berg, Sára Bech, Jan O. Aasly, Matthew J. Farrer, Maria Skaalum Petersen
SSRN Electronic Journal .2021;[Epub] CrossRef
Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2
Hui-Jun Yang, Han-Joon Kim, Seong-Beom Koh, Joong-Seok Kim, Tae-Beom Ahn, Sang-Myung Cheon, Jin Whan Cho, Yoon-Joong Kim, Hyeo-Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, In-Uk Song, Ji-Young Kim, Young-Hee Sung, Do You
Journal of Clinical Neurology.2020; 16(1): 66. CrossRef
Risk Factors for Falls in Patients with de novo Parkinson’s Disease: A Focus on Motor and Non-Motor Symptoms
Kyum-Yil Kwon, Mina Lee, Hyunjin Ju, Kayeong Im
Journal of Movement Disorders.2020; 13(2): 142. CrossRef
Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder
Ryul Kim, Jin‐Sun Jun, Han‐Joon Kim, Ki‐Young Jung, Yong‐Won Shin, Tae‐Won Yang, Keun Tae Kim, Tae‐Joon Kim, Jung‐Ick Byun, Jun‐Sang Sunwoo, Beomseok Jeon
Movement Disorders.2019; 34(11): 1739. CrossRef
Urinary Dysfunctions and Post-Void Residual Urine in Typical and Atypical Parkinson Diseases
Yang-Hyun Lee, Jee-Eun Lee, Dong-Woo Ryu, Yoon-Sang Oh, Kwang-Soo Lee, Sung-Hoo Hong, Joong-Seok Kim
Journal of Parkinson's Disease.2018; 8(1): 145. CrossRef
Rasch Analysis of the Clinimetric Properties of the Korean Dizziness Handicap Inventory in Patients with Parkinson Disease
Da-Young Lee, Hui-Jun Yang, Dong-Seok Yang, Jin-Hyuk Choi, Byoung-Soo Park, Ji-Yun Park
Research in Vestibular Science.2018; 17(4): 152. CrossRef
Clinical Characteristics of Parkinson’s Disease Developed from Essential Tremor
Dong-Woo Ryu, Si-Hoon Lee, Yoon-Sang Oh, Jae-Young An, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee, Joong-Seok Kim
Journal of Parkinson's Disease.2017; 7(2): 369. CrossRef

Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson’s Disease: Kyum-Yil Kwon, Seon Jong Pyo, Hye Mi Lee, Woo-Keun Seo, Seong-Beom Koh; J Mov Disord. 2016;9(3):144-151. Published online September 21, 2016; DOI: https://doi.org/10.14802/jmd.16012

13,407 View
122 Download
8 Web of Science
8 Crossref

Abstract PDF Supplementary Material

Objective
We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).
Methods
We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.
Results
Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.
Conclusion
This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

Citations

Citations to this article as recorded by

Association between the blood pressure variability and cognitive decline in Parkinson's disease
Yi Xiao, Tianmi Yang, Lingyu Zhang, Qianqian Wei, Ruwei Ou, Yanbing Hou, Kuncheng Liu, Junyu Lin, Qirui Jiang, Huifang Shang
Brain and Behavior.2023;[Epub] CrossRef
Cardiovascular autonomic dysfunction is associated with executive dysfunction and poorer quality of life in progressive supranuclear palsy-Richardson’s syndrome
Peng Liu, Yueting Chen, Bo Wang, Sheng Wu, Leilei Zeng, Zhidong Cen, Dehao Yang, Haotian Wang, Xinhui Chen, Lebo Wang, Zhiyuan Ouyang, Wei Luo
Journal of Clinical Neuroscience.2022; 96: 147. CrossRef
Blood Pressure Variability and Cognitive Function: a Scoping Review
Nur Fazidah Asmuje, Sumaiyah Mat, Phyo Kyaw Myint, Maw Pin Tan
Current Hypertension Reports.2022; 24(10): 375. CrossRef
Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
Kyum-Yil Kwon, Suyeon Park, Rae On Kim, Eun Ji Lee, Mina Lee
Scientific Reports.2022;[Epub] CrossRef
Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
Yerim Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Ji Sung Lee, Jong-Ho Park, Yong-Jae Kim, Joung-Ho Rha, Yang-Ha Hwang, Sung Hyuk Heo, Seong Hwan Ahn, Ju-Hun Lee, Sun U. Kwon
Scientific Reports.2021;[Epub] CrossRef
The correlation of blood pressure variability and cognitive function in hypertension patients: A meta‐analysis
Xiaojie Jin, Yi Lu, Peng Zhao
International Journal of Clinical Practice.2021;[Epub] CrossRef
Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study
Pedro Pallangyo, Zabella S. Mkojera, Makrina Komba, Lucy R. Mgopa, Smita Bhalia, Henry Mayala, Salma Wibonela, Nsajigwa Misidai, Happiness J. Swai, Jalack Millinga, Ester Chavala, Peter R. Kisenge, Mohamed Janabi
BMC Neurology.2021;[Epub] CrossRef
Backward Gait is Associated with Motor Symptoms and Fear of Falling in Patients withDe NovoParkinson's Disease
Kyum-Yil Kwon, Suyeon Park, Hye Mi Lee, Young-Min Park, Jinhee Kim, Jaehwan Kim, Seong-Beom Koh
Journal of Clinical Neurology.2019; 15(4): 473. CrossRef

Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease: Hye Mi Lee, Seong-Beom Koh; J Mov Disord. 2015;8(2):92-97. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15003

22,370 View
543 Download
97 Web of Science
96 Crossref

Abstract PDF

Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.

Citations

Citations to this article as recorded by

Challenges in Managing Nonmotor Symptoms of Parkinson's Disease in Low‐Resourced Settings with Unavailability of Newer Drugs
Zakiyah Aldaajani, Hanan Khalil
Movement Disorders Clinical Practice.2024; 11(2): 123. CrossRef
Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?
Azyadeh Camacho-Ordonez, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Ana Jimena Hernandez-Medrano, Selma Alin Somilleda-Ventura, Hector J. Pérez-Cano, Ángel Nava-Castañeda, Oscar Guerrero-Berger
European Journal of Ophthalmology.2024; 34(1): 252. CrossRef
Robotic technology for Parkinson's disease: Needs, attitudes and concerns of individuals with Parkinson's disease and their family members. A focus group study
Azriel Kaplan, Shirel Barkan-Slater, Yair Zlotnik, Shelly Levy-Tzedek
International Journal of Human-Computer Studies.2024; 181: 103148. CrossRef
Associations of dual-task walking costs with cognition in Parkinson’s disease
Danial Kazemi, Amir Shayan Chadeganipour, Mina Dehghani, Fatemeh Ghorbali
Gait & Posture.2024; 110: 48. CrossRef
Lifestyle Modulators of Neuroplasticity in Parkinson’s Disease: Evidence in Human Neuroimaging Studies
Silvia Paola Caminiti, Silvia Gallo, Federico Menegon, Andrea Naldi, Cristoforo Comi, Giacomo Tondo
CNS & Neurological Disorders - Drug Targets.2024; 23(5): 602. CrossRef
Buty and the beast: the complex role of butyrate in Parkinson’s disease
Joshua D. Elford, Nanette Becht, Johan Garssen, Aletta D. Kraneveld, Paula Perez-Pardo
Frontiers in Pharmacology.2024;[Epub] CrossRef
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Prapti Chakraborty, Hasinika K.A.H. Gamage, Angela S. Laird
Neurochemistry International.2024; 176: 105745. CrossRef
Neuroprotective effect of anethole against rotenone induced non-motor deficits and oxidative stress in rat model of Parkinson’s disease
Sadegh Moradi Vastegani, Seyed Esmaeil Khoshnam, Esrafil Mansouri, Somayeh Hajipour, Samireh Ghafouri, Nima Bakhtiari, Alireza Sarkaki, Yaghoob Farbood
Behavioural Brain Research.2023; 437: 114100. CrossRef
The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson’s disease: A double-blind, placebo-controlled, randomized controlled trial
Sanaz Mehrabani, Fariborz Khorvash, Zahra Heidari, Maryam Tajabadi-Ebrahimi, Reza Amani
Journal of Functional Foods.2023; 100: 105397. CrossRef
Role of Ceramides and Sphingolipids in Parkinson's Disease
Melissa Vos, Christine Klein, Andrew A Hicks
Journal of Molecular Biology.2023; 435(12): 168000. CrossRef
Efficacy of herbal medicine treatment based on syndrome differentiation for Parkinson’s disease: A systematic review and meta-analysis of randomized placebo-controlled clinical trials
Purumea Jun, HuiYan Zhao, In Chul Jung, Ojin Kwon, Chang-Hyun Han, Jiyoon Won, Jung-Hee Jang
Frontiers in Pharmacology.2023;[Epub] CrossRef
A meta-analysis of exercise intervention and the effect on Parkinson’s Disease symptoms
Syed Omar Ahmad, Jason Longhurst, Dana Stiles, Lana Downard, Stephanie Martin
Neuroscience Letters.2023; 801: 137162. CrossRef
Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Zavos, Evangelos Kazakos, Stergios Arapoglou, Foteini Kyrailidi, Maria C. Mouratidou, Marina Boziki, Elisabeth Vardaka
Medicina.2023; 59(3): 504. CrossRef
Case management interventions in chronic disease reduce anxiety and depressive symptoms: A systematic review and meta-analysis
Angelika D. Geerlings, Jules M. Janssen Daalen, Jan H. L. Ypinga, Bastiaan R. Bloem, Marjan J. Meinders, Marten Munneke, Sirwan K. L. Darweesh, Vincenzo De Luca
PLOS ONE.2023; 18(4): e0282590. CrossRef
Bio-synthesized selenium nanoparticles ameliorate Brain oxidative stress in Parkinson disease rat models
Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
Metabolic Brain Disease.2023; 38(6): 2055. CrossRef
Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence
Poornima D.E. Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Changjong Moon
Current Neuropharmacology.2023; 21(3): 560. CrossRef
Psychosis in Parkinson’s Disease and Current Management Trends- an Updated Review of Literature
Dutta Rajib
Journal of Neuroscience and Neurological Disorders.2023; 7(2): 027. CrossRef
The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson’s Disease Pathogenesis
Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Santiago Cadena-Ullauri, Evelyn Frias-Toral, Patricia Guevara-Ramírez, Elius Paz-Cruz, Sebastián Chapela, Martha Montalván, Tania Morales-López, Daniel Simancas-Racines, Ana Karina Zambrano
Nutrients.2023; 15(16): 3585. CrossRef
Enhancing Parkinson's disease severity assessment through voice-based wavelet scattering, optimized model selection, and weighted majority voting
Farhad Abedinzadeh Torghabeh, Seyyed Abed Hosseini, Elham Ahmadi Moghadam
Medicine in Novel Technology and Devices.2023; 20: 100266. CrossRef
A look back at the prodromal findings in Parkinson’s disease
Seyed-Amirabbas Ahadiat, Zeinab Hosseinian
Bulletin of the National Research Centre.2023;[Epub] CrossRef
Parkinson’s Disease Non-Motor Subtypes Classification in a Group of Slovenian Patients: Actuarial vs. Data-Driven Approach
Timotej Petrijan, Jan Zmazek, Marija Menih
Journal of Clinical Medicine.2023; 12(23): 7434. CrossRef
Unveiling the Hidden Challenges: Non-Motor Disorders in Parkinson’s Disease
Francisco Nieto-Escamez, Esteban Obrero-Gaitán, Héctor García-López, Irene Cortés-Pérez
Brain Sciences.2023; 13(12): 1710. CrossRef
REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
Aging Clinical and Experimental Research.2022; 34(1): 159. CrossRef
Gender Differences and Impact of Autonomic Disturbance on Fatigue and Quality of Life in Parkinson's Disease
NahushR Bansal, BirinderS Paul, Gunchan Paul, Gagandeep Singh
Neurology India.2022; 70(1): 203. CrossRef
Exploring Unmet Information Needs of People with Parkinson’s Disease and Their Families: Focusing on Information Sharing in an Online Patient Community
Hyeon Sik Chu, Hye Young Jang
International Journal of Environmental Research and Public Health.2022; 19(5): 2521. CrossRef
Gut microbiota and inflammation in Parkinson’s disease: Pathogenetic and therapeutic insights
Tong Guo, Li Chen
European Journal of Inflammation.2022; 20: 1721727X2210837. CrossRef
Diffusion Tensor Imaging Reveals Deep Brain Structure Changes in Early Parkinson’s Disease Patients with Various Sleep Disorders
Yanyan Jiang, Hedi An, Qian Xi, Weiting Yang, Hongrong Xie, Yang Li, Dongya Huang
Brain Sciences.2022; 12(4): 463. CrossRef
Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism
Hae-Won Shin, Sang-Wook Hong, Young Chul Youn
Journal of Clinical Neurology.2022; 18(3): 259. CrossRef
Effect of mobile health intervention for self-management on self-efficacy, motor and non-motor symptoms, self-management, and quality of life in people with Parkinson's disease: Randomized controlled trial
Yusun Park, Sung Reul Kim, Hui Young So, Sungyang Jo, Seung Hyun Lee, Yun su Hwang, Mi Sun Kim, Sun Ju Chung
Geriatric Nursing.2022; 46: 90. CrossRef
Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders
Milind V. Masule, Sumit Rathod, Yogeeta Agrawal, Chandragouda R. Patil, Kartik T. Nakhate, Shreesh Ojha, Sameer N. Goyal, Umesh B. Mahajan
Current Research in Pharmacology and Drug Discovery.2022; 3: 100113. CrossRef
Psychosis in Parkinson’s Disease: A Lesson from Genetics
Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou, Chiara Villa
Genes.2022; 13(6): 1099. CrossRef
Non-motor manifestation of Parkinson's disease: a cross-sectional study in a teaching hospital in Jordan
Said Salah Dahbour, Mohammad J. Al Murr, Liyan H. Oweis, Nada T. Al Antary, Maram Mohsen, Safa Al Fegi
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2022;[Epub] CrossRef
Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study
Esmail Alipour Nosrani, Omid Reza Tamtaji, Zahra Alibolandi, Parichehr Sarkar, Mohsen Ghazanfari, Abolfazl Azami Tameh, Mohsen Taghizadeh, Zarrin Banikazemi, Razie Hadavi, Mojtaba Naderi Taheri
Journal of Immunoassay and Immunochemistry.2021; 42(2): 106. CrossRef
SURINPARK: Safinamide for Urinary Symptoms in Parkinson’s Disease
Ana Gómez-López, Arantxa Sánchez-Sánchez, Elena Natera-Villalba, Victoria Ros-Castelló, Álvaro Beltrán-Corbellini, Samira Fanjul-Arbós, Isabel Pareés Moreno, José Luis López-Sendon Moreno, Juan Carlos Martínez Castrillo, Araceli Alonso-Canovas
Brain Sciences.2021; 11(1): 57. CrossRef
People with Parkinson’s Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration?
Rebecca J. Port, Martin Rumsby, Graham Brown, Ian F. Harrison, Anneesa Amjad, Claire J. Bale
Journal of Parkinson's Disease.2021; 11(2): 715. CrossRef
Rho‐kinase inhibition by fasudil modulates pre‐synaptic vesicle dynamics
Kim Ann Saal, Carmina Warth Pérez Arias, Anna‐Elisa Roser, Jan Christoph Koch, Mathias Bähr, Silvio O. Rizzoli, Paul Lingor
Journal of Neurochemistry.2021; 157(4): 1052. CrossRef
A Comprehensive Phenotype of Non-motor Impairments and Distribution of Alpha-Synuclein Deposition in Parkinsonism-Induced Mice by a Combination Injection of MPTP and Probenecid
Na-Ra Han, Yu-Kang Kim, Sora Ahn, Tae-Yeon Hwang, Hyejung Lee, Hi-Joon Park
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef
Association of Parkinson’s Disease With Microbes and Microbiological Therapy
Zhao-Ji Chen, Cheng-Yu Liang, Li-Qing Yang, Si-Min Ren, Yan-Min Xia, Lei Cui, Xiao-Fang Li, Bu-Lang Gao
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Plasma Lipopolysaccharide-Binding Protein Reflects Risk and Progression of Parkinson’s Disease
Szu-Ju Chen, Yu-Chiao Chi, Chang-Han Ho, Wei-Shiung Yang, Chin-Hsien Lin
Journal of Parkinson's Disease.2021; 11(3): 1129. CrossRef
The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease
Melissa Vos, Christine Klein
Cells.2021; 10(3): 579. CrossRef
Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
Verónica Sambra, Francisca Echeverria, Alfonso Valenzuela, Raphaël Chouinard-Watkins, Rodrigo Valenzuela
Nutrients.2021; 13(3): 986. CrossRef
What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
Paola Tirassa, Tommaso Schirinzi, Marcello Raspa, Massimo Ralli, Antonio Greco, Antonella Polimeni, Roberta Possenti, Nicola Biagio Mercuri, Cinzia Severini
Neuroscience & Biobehavioral Reviews.2021; 131: 899. CrossRef
Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway
Xiaoyue Zhao, Dewen Kong, Qimeng Zhou, Guangyi Wei, Junke Song, Yu Liang, Guanhua Du
Biomedicine & Pharmacotherapy.2021; 140: 111556. CrossRef
Apathy and actions- another consideration when theorizing about embodied nature of language in Parkinson's disease
Logan Wolff, Jared F. Benge, Samia Ortiz-Hernandez, Samantha Beevers, Alexandra Armitage, Jungjun Park, Daniel L. Drane
Journal of Communication Disorders.2021; 93: 106144. CrossRef
Association analysis and polygenic risk score evaluation of 38 GWAS-identified Loci in a Chinese population with Parkinson’s disease
Ran Zheng, Song Qiao, Ying Chen, Chongyao Jin, Yi Fang, Zhihao Lin, Naijia Xue, Yiqun Yan, Luyan Gu, Ting Gao, Jun Tian, Yaping Yan, Xinzhen Yin, Jiali Pu, Baorong Zhang
Neuroscience Letters.2021; 762: 136150. CrossRef
Non-motor impairments affect walking kinematics in Parkinson disease patients: A cross-sectional study
Sara Liguori, Antimo Moretti, Angela Palomba, Marco Paoletta, Francesca Gimigliano, Rosa De Micco, Mattia Siciliano, Alessandro Tessitore, Giovanni Iolascon
NeuroRehabilitation.2021; 49(3): 481. CrossRef
The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
Qing Wang, Yuqi Luo, K Ray Chaudhuri, Richard Reynolds, Eng-King Tan, Sven Pettersson
Brain.2021; 144(9): 2571. CrossRef
Clinical features contributing to the sit-to-stand transfer in people with Parkinson’s disease: a systematic review
Charmaine Pearl Da Cunha, Pratiksha Tilak Rao, Suruliraj Karthikbabu
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef
Integration of Aluminium Interdigitated Electrodes with Zinc Oxide as Nanocomposite for Selectively Detect Alpha-Synuclein for Parkinson’s Disease Diagnosis
Hussaini Adam, Subash C. B Gopinath, Uda Hashim
Journal of Physics: Conference Series.2021; 2129(1): 012094. CrossRef
Effects of depression and exercise on health-related quality of life in patients with Parkinson's disease
George W Koutsouras, Kimberly Levine, Nathalie Duroseau, Christina Ciraco, Vivian Chan, Kathleen Pergament, Thomas Chan, Jayme D Mancini, Adena N Leder, Bhuma Krishnamachari
Chronic Illness.2020; 16(3): 190. CrossRef
Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo
Arun Kumar Mahato, Jaakko Kopra, Juho‐Matti Renko, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Andrii Domanskyi, Eric Ronken, T. Petteri Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati Karelson, Yulia A. Sidorova, Mart Saar
Movement Disorders.2020; 35(2): 245. CrossRef
Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-induced Parkinsonism in rats
Xiao-Jun Feng, Yu-Ting Huang, Ying-Zu Huang, Chi-Wei Kuo, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Yuan-Hao Chen, Kai-Yun Chen, Yung-Hsiao Chiang, Hui-Hua Liu, Jian-Xian Wu, Tsung-Hsun Hsieh
Brain Stimulation.2020; 13(3): 655. CrossRef
Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
Geriatrics & Gerontology International.2020; 20(5): 443. CrossRef
The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho
Journal of Parkinson's Disease.2020; 10(2): 605. CrossRef
Assessments of plasma acyl-ghrelin levels in Parkinson’s disease patients treated with deep brain stimulation
Wojciech Pietraszko, Agata Furgala, Agnieszka Gorecka-Mazur, Borys Kwinta, Jolanta Kaszuba-Zwoinska, Jaroslaw Polak, Urszula Fiszer, Krzysztof Gil, Anna Krygowska-Wajs
Peptides.2020; 128: 170299. CrossRef
Common and unique connectivity at the interface of motor, neuropsychiatric, and cognitive symptoms in Parkinson's disease: A commonality analysis
Stefan Lang, Zahinoor Ismail, Mekale Kibreab, Iris Kathol, Justyna Sarna, Oury Monchi
Human Brain Mapping.2020; 41(13): 3749. CrossRef
Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases
Dorines Rosario, Jan Boren, Mathias Uhlen, Gordon Proctor, Dag Aarsland, Adil Mardinoglu, Saeed Shoaie
Frontiers in Neuroscience.2020;[Epub] CrossRef
Rpt2 proteasome subunit reduction causes Parkinson's disease like symptoms in Drosophila
Iván Fernández-Cruz, Iván Sánchez-Díaz, Verónica Narváez-Padilla, Enrique Reynaud
IBRO Reports.2020; 9: 65. CrossRef
Boxing to Improve Sleep Quality and Daytime Sleepiness in Individuals With Parkinson Disease
Macy Urrutia, Cynthia Ivy, Patricia S. Pohl, Linda Denney
Topics in Geriatric Rehabilitation.2020; 36(3): 170. CrossRef
Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
Vanessa Castelli, Michele d’Angelo, Francesca Lombardi, Margherita Alfonsetti, Andrea Antonosante, Mariano Catanesi, Elisabetta Benedetti, Paola Palumbo, Maria Grazia Cifone, Antonio Giordano, Giovambattista Desideri, Annamaria Cimini
Aging.2020; 12(5): 4641. CrossRef
Depressive symptoms are associated with worse cognitive prognosis in patients with newly diagnosed idiopathic Parkinson disease
Jeong Hoon Park, Seung Hwan Lee, Yeshin Kim, Sang‐Won Park, Gi Hwan Byeon, Jae‐Won Jang
Psychogeriatrics.2020; 20(6): 880. CrossRef
Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions
Soo Bin Park, Kyum-Yil Kwon, Jeong-Yoon Lee, Kayeong Im, Jun-Sang Sunwoo, Kyung Bok Lee, Hakjae Roh, Moo-Young Ahn, Suyeon Park, Soo-Jong Kim, Jungsu S. Oh, Jae Seung Kim
Neurological Sciences.2019; 40(2): 311. CrossRef
Cognitive Problems in Parkinson Disease: Perspectives and Priorities of Patients and Care Partners
Katrina L. Raein, Samia Ortiz-Hernández, Jared F. Benge
Cognitive and Behavioral Neurology.2019; 32(1): 16. CrossRef
Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity
Sunil Srivastav, Sabita Neupane, Sunil Bhurtel, Nikita Katila, Sailesh Maharjan, Hyukjae Choi, Jin Tae Hong, Dong-Young Choi
The Journal of Nutritional Biochemistry.2019; 69: 73. CrossRef
Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore
Journal of Movement Disorders.2019; 12(2): 84. CrossRef
Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases
Alon Seifan, Christine A. Ganzer, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R. Jacobs, Molly Greenwald, Richard S. Isaacson
Current Aging Science.2019; 11(4): 242. CrossRef
Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease
Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, Ryan S. Anderton
Parkinson's Disease.2019; 2019: 1. CrossRef
α-Synuclein in Parkinson’s disease: causal or bystander?
Peter Riederer, Daniela Berg, Nicolas Casadei, Fubo Cheng, Joseph Classen, Christian Dresel, Wolfgang Jost, Rejko Krüger, Thomas Müller, Heinz Reichmann, Olaf Rieß, Alexander Storch, Sabrina Strobel, Thilo van Eimeren, Hans-Ullrich Völker, Jürgen Winkler,
Journal of Neural Transmission.2019; 126(7): 815. CrossRef
Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease
Motoki Okano, Kazue Takahata, Junya Sugimoto, Shizuko Muraoka
Frontiers in Behavioral Neuroscience.2019;[Epub] CrossRef
Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease
Mi Sun Sung, Seong-Min Choi, Jonghwa Kim, Jun Young Ha, Byeong-Chae Kim, Hwan Heo, Sang Woo Park
Scientific Reports.2019;[Epub] CrossRef
Probiotics for Parkinson’s Disease
Gazerani
International Journal of Molecular Sciences.2019; 20(17): 4121. CrossRef
The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang
Frontiers in Neurology.2019;[Epub] CrossRef
Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease
Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh
Behavioural Neurology.2019; 2019: 1. CrossRef
The effectiveness of istradefylline for the treatment of gait deficits and sleepiness in patients with Parkinson’s disease
Keita Matsuura, Hiroyuki Kajikawa, Ken-ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
Neuroscience Letters.2018; 662: 158. CrossRef
Predictors of Mortality in Nondemented Patients With Parkinson Disease: Motor Symptoms Versus Nonmotor Symptoms
D. Santos-García, E. Suárez-Castro, J. Ernandez, I. Expósito-Ruiz, C. Tuñas-Gesto, M. Aneiros-Díaz, T. de Deus-Fonticoba, M. López-Fernández, D. Núñez-Arias
Journal of Geriatric Psychiatry and Neurology.2018; 31(1): 19. CrossRef
Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson’s Disease
Paula Perez-Pardo, Laus M. Broersen, Tessa Kliest, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
Frontiers in Aging Neuroscience.2018;[Epub] CrossRef
Ghrelin and Neurodegenerative Disorders—a Review
Limin Shi, Xixun Du, Hong Jiang, Junxia Xie
Molecular Neurobiology.2017; 54(2): 1144. CrossRef
The neurological effects of ghrelin in brain diseases: Beyond metabolic functions
Qian Jiao, Xixun Du, Yong Li, Bing Gong, Limin Shi, Tingting Tang, Hong Jiang
Neuroscience & Biobehavioral Reviews.2017; 73: 98. CrossRef
First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
Dale B. Schenk, Martin Koller, Daniel K. Ness, Sue G. Griffith, Michael Grundman, Wagner Zago, Jay Soto, George Atiee, Susanne Ostrowitzki, Gene G. Kinney
Movement Disorders.2017; 32(2): 211. CrossRef
Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee
European Journal of Neurology.2017; 24(2): 349. CrossRef
α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects
Joong-Seok Kim, In-Seok Park, Hyung-Eun Park, Su-Young Kim, Jung A Yun, Chan Kwon Jung, Hye-Young Sung, Jin-Kwon Lee, Won-Kyung Kang
Neurological Sciences.2017; 38(1): 171. CrossRef
Use of monoamine oxidase inhibitors in chronic neurodegeneration
Peter Riederer, Thomas Müller
Expert Opinion on Drug Metabolism & Toxicology.2017; 13(2): 233. CrossRef
Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
Journal of Movement Disorders.2017; 10(1): 29. CrossRef
Retinal biomarkers provide “insight” into cortical pharmacology and disease
Christine T.O. Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K. van Koeverden, Jeremiah K.H. Lim, Zheng He, Vickie H.Y. Wong, Algis J. Vingrys, Bang V. Bui, Magnus Ivarsson
Pharmacology & Therapeutics.2017; 175: 151. CrossRef
Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease
Paula Perez-Pardo, Esther M. de Jong, Laus M. Broersen, Nick van Wijk, Amos Attali, Johan Garssen, Aletta D. Kraneveld
Frontiers in Aging Neuroscience.2017;[Epub] CrossRef
DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers
Moran Artzi, Einat Even-Sapir, Hedva Lerman Shacham, Avner Thaler, Avi Orr Urterger, Susan Bressman, Karen Marder, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Anat Mirelman, Elisa Greggio
PLOS ONE.2017; 12(4): e0175424. CrossRef
The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies
Paula Perez-Pardo, Tessa Kliest, Hemraj B. Dodiya, Laus M. Broersen, Johan Garssen, Ali Keshavarzian, Aletta D. Kraneveld
European Journal of Pharmacology.2017; 817: 86. CrossRef
Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms
Mayela Rodríguez-Violante, Rosalía Zerón-Martínez, Amin Cervantes-Arriaga, Teresa Corona
Archives of Medical Research.2017; 48(3): 221. CrossRef
Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease
Paula Perez-Pardo, Mitch Hartog, Johan Garssen, Aletta D. Kraneveld
Current Behavioral Neuroscience Reports.2017; 4(4): 361. CrossRef
The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
Gretchen O. Reynolds, Michael W. Otto, Terry D. Ellis, Alice Cronin‐Golomb
Movement Disorders.2016; 31(1): 23. CrossRef
Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef
Relearning of Writing Skills in Parkinson's Disease After Intensive Amplitude Training
Evelien Nackaerts, Elke Heremans, Griet Vervoort, Bouwien C.M. Smits‐Engelsman, Stephan P. Swinnen, Wim Vandenberghe, Bruno Bergmans, Alice Nieuwboer
Movement Disorders.2016; 31(8): 1209. CrossRef
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
Journal of Movement Disorders.2016; 9(2): 97. CrossRef
The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
Journal of Clinical Neurology.2016; 12(4): 393. CrossRef
Bent out of shape: α‐Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease
Esteban Luna, Kelvin C. Luk
FEBS Letters.2015; 589(24PartA): 3749. CrossRef
Differentiated Cells Derived from Fetal Neural Stem Cells Improve Motor Deficits in a Rat Model of Parkinson's Disease
Wei Wang, Hao Song, Aifang Shen, Chao Chen, Yanming Liu, Yabing Dong, Fabin Han
Translational Neuroscience and Clinics.2015; 1(2): 75. CrossRef

Clinical Features and Disability Milestones in Multiple System Atrophy and Progressive Supranuclear Palsy: Sang-Wook Lee, Seong-Beom Koh; J Mov Disord. 2012;5(2):42-47.; DOI: https://doi.org/10.14802/jmd.12010

23,708 View
136 Download
12 Crossref

Abstract PDF

Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are an adult-onset progressive neurodegenerative disorder that are known to display diverse clinical features and disease progression. We aim to characterize the clinical features and disease progression in patients with MSA and PSP by using a number of relevant disability milestones in Koreans. Forty-one patients with MSA and 14 patients with PSP had been enrolled. The mean age at onset of MSA-C, MSA-P and PSP was 56.7 ± 7.8, 62.5 ± 8.0, 68.9 ± 6.1 years respectively. The most commonly reported symptom at disease onset is disequilibrium/dizziness in MSA-C, tremor in MSA-P and frequent falling in PSP. The mean duration of reaching milestones after disease onset in MSA-C were as followings: 20.8 (urinary incontinence), 22.9 (frequent falling), 27.8 (wheelchair bound), 31.8 (dysarthria) and 35.8 months (diagnosis). The mean duration of reaching milestones after disease onset were 22.0 (urinary incontinence), 32.6 (frequent falling and diagnosis), 41.2 (dysarthria), 61.4 months (wheelchair bound) in MSA-P and 16.8 (dysarthria), 21.6 (diagnosis), 21.7 (frequent falling), 24.0 months (wheel chair bound) in PSP. In the case of MSA, dizziness may occur for the first time. Thus, when the patient complains of non-specific dizziness, a follow-up examination to distinguish it from MSA can be helpful. There was a trend for patients with MSA-C to reach more disability milestones than in MSA-P and PSP before diagnosis. It may explain why patients with MSA-C are required more detail history taking and neurologic examination at an earlier stage.

Citations

Citations to this article as recorded by

Disease course and treatment patterns in progressive supranuclear palsy: A real-world study
John C. Morgan, Xiaolan Ye, Jennifer A. Mellor, Keisha J. Golden, Jorge Zamudio, Louis A. Chiodo, Yanjun Bao, Tao Xie
Journal of the Neurological Sciences.2021; 421: 117293. CrossRef
Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy
Hui Jae Do, Han Gil Seo, Hyun Haeng Lee, Byung-Mo Oh, Yoon Kim, Aryun Kim, Han-Joon Kim, Beomseok Jeon, Tai Ryoon Han
Dysphagia.2020; 35(1): 24. CrossRef
Is There a Difference in Autonomic Dysfunction Between Multiple System Atrophy Subtypes?
Divyani Garg, Achal Kumar Srivastava, Ashok Kumar Jaryal, Roopa Rajan, Akanksha Singh, Awadh Kishor Pandit, Deepti Vibha, Garima Shukla, Ajay Garg, Ravindra Mohan Pandey, Kameshwar Prasad
Movement Disorders Clinical Practice.2020; 7(4): 405. CrossRef
Models of multiple system atrophy
He-Jin Lee, Diadem Ricarte, Darlene Ortiz, Seung-Jae Lee
Experimental & Molecular Medicine.2019; 51(11): 1. CrossRef
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1
Kurt A. Jellinger, George Perry, Jesus Avila, Massimo Tabaton, Xiongwei Zhu
Journal of Alzheimer's Disease.2018; 62(3): 1141. CrossRef
Present and future of disease-modifying therapies in multiple system atrophy
Miguel Lopez-Cuina, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner
Autonomic Neuroscience.2018; 211: 31. CrossRef
Different subregional metabolism patterns in patients with cerebellar ataxia by 18F-fluorodeoxyglucose positron emission tomography
Minyoung Oh, Jae Seung Kim, Jungsu S. Oh, Chong Sik Lee, Sun Ju Chung, Byeong-Cheol Ahn
PLOS ONE.2017; 12(3): e0173275. CrossRef
Vestibular Deficits in Neurodegenerative Disorders: Balance, Dizziness, and Spatial Disorientation
Thomas Cronin, Qadeer Arshad, Barry M. Seemungal
Frontiers in Neurology.2017;[Epub] CrossRef
Progressive supranuclear palsy: progression and survival
Julieta E. Arena, Stephen D. Weigand, Jennifer L. Whitwell, Anhar Hassan, Scott D. Eggers, Günter U. Höglinger, Irene Litvan, Keith A. Josephs
Journal of Neurology.2016; 263(2): 380. CrossRef
Multiple system atrophy: pathogenic mechanisms and biomarkers
Kurt A. Jellinger, Gregor K. Wenning
Journal of Neural Transmission.2016; 123(6): 555. CrossRef
Urinary Dysfunction in Progressive Supranuclear Palsy Compared with Other Parkinsonian Disorders
Tatsuya Yamamoto, Fuyuki Tateno, Ryuji Sakakibara, Shogo Furukawa, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Yoshitaka Yamanaka, Miki Fuse, Yasuko Koga, Mitsuru Yanagisawa, Satoshi Kuwabara, Jong-Ling Fuh
PLOS ONE.2016; 11(2): e0149278. CrossRef
Movement and Other Neurodegenerative Syndromes in Patients with Systemic Rheumatic Diseases
Rikitha Menezes, Alexander Pantelyat, Izlem Izbudak, Julius Birnbaum
Medicine.2015; 94(31): e0971. CrossRef

Generalized Chorea Induced by an Unilateral Anterior Cerebral Artery Territorial Infarction: Jae Hong Chang, Woo-Keun Seo, Moon-Ho Park, Jong-Mun Lee, Do-Young Kwon, Seong-Beom Koh; J Mov Disord. 2009;2(1):37-39.; DOI: https://doi.org/10.14802/jmd.09009

8,988 View
85 Download
3 Crossref

Abstract PDF

Generalized chorea caused by unilateral cerebral infarction has rarely been reported. A 58-year-old woman presented involuntary movement in her all extremities after acute cerebral infarction on her right anterior cerebral artery territory. The involuntary movements were diagnosed as generalized chorea. We didn’t find any cause of generalized chorea except the acute cerebral infarction. Here, we described the case of generalized chorea after unilateral cerebral infarction discussing the possible mechanisms.

Citations

Citations to this article as recorded by

Cerebral infarction in centrum semiovale presenting with hemichorea: a case report and literature review
Jingjing Yi, Lingru Zhang, Tao Zhang, Jianfeng Li, Yifan Zhang, Meining Zhou
Frontiers in Neurology.2023;[Epub] CrossRef
Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study
Kye Won Park, Nari Choi, Eungseok Oh, Chul Hyoung Lyoo, Min Seok Baek, Han-Joon Kim, Dalla Yoo, Jee-Young Lee, Ji-Hyun Choi, Jae Hyeok Lee, Seong-Beom Koh, Young Hee Sung, Jin Whan Cho, Hui-Jun Yang, Jinse Park, Hae-Won Shin, Tae-Beom Ahn, Ho-Sung Ryu, So
Frontiers in Neurology.2022;[Epub] CrossRef
Acute Hemichorea as an Unusual Presentation of Internal Carotid Artery Stenosis
Dong Wook Kim, Youngchai Ko, Sang Hyun Jang, Soo Jin Yoon, Gun-Sei Oh, Soo Joo Lee, Dong Joo Yun
Journal of Movement Disorders.2013; 6(1): 17. CrossRef

Gait Analysis in Patients With Parkinson’s Disease: Relationship to Clinical Features and Freezing: Seong-Beom Koh, Kun-Woo Park, Dae-Hie Lee, Se Ju Kim, Joon-Shik Yoon; J Mov Disord. 2008;1(2):59-64.; DOI: https://doi.org/10.14802/jmd.08011

17,389 View
433 Download
12 Crossref

Abstract PDF

Background:

The purpose of our study was to investigate gait dynamics and kinematics in patients with Parkinson’s disease (PD) and to correlate these features with the predominant clinical features and with the presence of the freezing of gait (FOG). We measured the temporospatial and kinematic parameters of gait in 30 patients with PD (M:F=12:18, age=68.43±7.54) using a computerized video motion analysis system.

Methods:

We divided the subjects into subgroups: (1) tremor-dominant (TD) group and postural instability and gait disturbance (PIGD) group and (2) FOG group and non-FOG group. We compared the gait parameters between the subgroups.

Results:

The walking velocity and stride length were reduced significantly in the PIGD group compared to the TD group. The PIGD group showed a significantly reduced range of motion in the pelvic and lower extremity joints by kinematics. Stride time variability was significantly increased and the pelvic oblique range was significantly reduced in the freezing gait disorder group.

Conclusion:

Our findings suggest that there are differences in the perturbation of the basal ganglia-cortical circuits based on major clinical features. The reduction of the pelvic oblique range of motion may be a compensatory mechanism for postural instability and contributes to stride time variability in patients with FOG.

Citations

Citations to this article as recorded by

A machine learning model for prediction of sarcopenia in patients with Parkinson’s Disease
Minkyeong Kim, Doeon Kim, Heeyoung Kang, Seongjin Park, Shinjune Kim, Jun-Il Yoo, Kyung-Wan Baek
PLOS ONE.2024; 19(1): e0296282. CrossRef
Machine learning approach for predicting state transitions via shank acceleration data during freezing of gait in Parkinson’s disease
Ashima Khosla, Neelesh Kumar, Preeti Khera
Biomedical Signal Processing and Control.2024; 92: 106053. CrossRef
The gait parameters in patients with Parkinson’s Disease under STN-DBS therapy and associated clinical features
Halil Onder, Ege Dinc, Kubra Yucesan, Selcuk Comoglu
Neurological Research.2023; 45(8): 779. CrossRef
Proof of Concept in Artificial-Intelligence-Based Wearable Gait Monitoring for Parkinson’s Disease Management Optimization
Robert Radu Ileșan, Claudia-Georgiana Cordoș, Laura-Ioana Mihăilă, Radu Fleșar, Ana-Sorina Popescu, Lăcrămioara Perju-Dumbravă, Paul Faragó
Biosensors.2022; 12(4): 189. CrossRef
Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: A Novel Deep One-Class Classifier
Nader Naghavi, Eric Wade
IEEE Journal of Biomedical and Health Informatics.2022; 26(4): 1726. CrossRef
Development of Neuro-Degenerative Diseases’ Gait Classification Algorithm Using Convolutional Neural Network and Wavelet Coherence Spectrogram of Gait Synchronization
Febryan Setiawan, An-Bang Liu, Che-Wei Lin
IEEE Access.2022; 10: 38137. CrossRef
Functional gait assessment in early and advanced Parkinson’s disease
Hany Mohamed Eldeeb, Heba Samir Abdelraheem
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef
Statistical methods for analysis of Parkinson’s disease gait pattern and classification
Anup Nandy
Multimedia Tools and Applications.2019; 78(14): 19697. CrossRef
Prediction of Freezing of Gait in Parkinson’s Disease Using Statistical Inference and Lower–Limb Acceleration Data
Nader Naghavi, Eric Wade
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2019; 27(5): 947. CrossRef
Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: Addressing the Class Imbalance Problem
Nader Naghavi, Aaron Miller, Eric Wade
Sensors.2019; 19(18): 3898. CrossRef
Computer-Vision Based Diagnosis of Parkinson’s Disease via Gait: A Survey
Navleen Kour, Sunanda, Sakshi Arora
IEEE Access.2019; 7: 156620. CrossRef
A comparison of soft computing models for Parkinson’s disease diagnosis using voice and gait features
Rekh Ram Janghel, Anupam Shukla, Chandra Prakash Rathore, Kshitiz Verma, Swati Rathore
Network Modeling Analysis in Health Informatics and Bioinformatics.2017;[Epub] CrossRef

Cruciform Pontine MRI Hyperintensities (“Hot Cross Bun” Sign) in Non-Multiple System Atrophy Patients: Seong-Beom Koh, Kun-Woo Park, Dae-Hie Lee; J Mov Disord. 2008;1(2):107-108.; DOI: https://doi.org/10.14802/jmd.08022

10,031 View
62 Download
1 Crossref

PDF

Citations

Citations to this article as recorded by

The “Hot Cross Bun Sign” in Spinocerebellar Ataxia Types 2 and 7–Case Reports and Review of Literature
Ansuya Kasavelu Naidoo, Cait‐Lynn Deanne Wells, Yashvir Rugbeer, Neil Naidoo
Movement Disorders Clinical Practice.2022; 9(8): 1105. CrossRef

Microglial Imaging in Movement Disorders With PK11195 PET: Seong-Beom Koh; J Mov Disord. 2008;1(1):1-5.; DOI: https://doi.org/10.14802/jmd.08001

9,681 View
137 Download

Abstract PDF: Activated microglia play a major role in the pathogenesis in neurological disorders. The transition of microglia from the normal resting state to the activated state is associated with an increased expression of receptors known as peripheral benzodiazepine binding sites, which are abundant on cells of mononuclear phagocyte lineage. PK11195 is a ligand which binds selectively to peripheral benzodiazepine binding sites, a type of receptor selectively expressed by activated microglia in the central nervous system. The ¹¹C-(R)-PK11195 positron emission tomography (PET) is already applied to many kinds of neurological disorders, including neurodegenerative disorders, and can demonstrate the role of neuroinflammation in the pathogenesis of neurological disorders. And this imaging modality also provides a means to monitor potential clinical relevance of antiinflammatory treatment strategies in vivo. This article reviews some of the clinical applications of ¹¹C-(R)-PK11195 PET in the field of movement disorders.

Evaluating the validity and reliability of the Korean version of Scales for Outcomes in Parkinson’s Disease–Cognition: Jinse Park, Eung Seok Oh, Seong-Beom Koh, In-Uk Song, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Yun Joong Kim, Jin Whan Cho, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Young Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Joong-Seok Kim, Ji-Young Kim; Received March 8, 2024 Accepted April 2, 2024 Published online April 3, 2024; DOI: https://doi.org/10.14802/jmd.24061 [Accepted]

411 View
16 Download

Abstract PDF: Objective
The Scales for Outcomes in Parkinson’s Disease–Cognition (SCOPA-Cog) was developed to screen for cognition in PD. In this study, we aimed to evaluate the validity and reliability of the Korean version of the SCOPA-cog.
Methods
We recruited 129 PD patients from 31 clinics with movement disorders in South Korea. The original version of the SCOPA-cognition was translated into Korean using the translation-retranslation method. The test-rest method with an intraclass correlation coefficient (ICC) and Cronbach’s alpha coefficient were used to assess reliability. The Spearman’s Rank correlation analysis with Montreal Cognitive Assessment-Korean version (MOCA-K) and Korean Mini-Mental State Examination (K-MMSE) were used to assess concurrent validity.
Results
The Cronbach’s alpha coefficient was 0.797, and the ICC was 0.887. Spearman’s rank correlation analysis showed a significant correlation with the K-MMSE and MOCA-K scores (r = 0.546 and r = 0.683, respectively).
Conclusions
Our results demonstrate that K-SCOPA-Cog exhibits good reliability and validity.

Author index